Hotline Miami 2: Wrong number is a sequel to Hotline Miami.

1985. There is a Cold war between the Soviet Union and the USA, which gradually turns into a hot war. In Hawaii, there are military operations. In the centre of the event, the squad "Ghost Wolves", which includes Dan Smith named "Beard", Jacket (the main character of the first part), and two soldiers. The United States, for this moment, are losing. The squad was ordered to capture the most dangerous Soviet zone.

As for the gameplay, a lot of details are borrowed from the first part, but unlike it, in the Wrong Number, there were levels of difficulty (classic and hard). The difficulty level unlocks after beating the game on classic difficulty. The difference is that all the levels are turned over, and contain more dangerous opponents.

The game has 13 playable characters. Each of them has their vision of the story, like Jacket and Biker in the original game. Masks from the first part appeared in the game again, and new masks that are giving new abilities were also added.