Resident Evil 4: Ultimate HD Edition is the second port of Resident Evil 4 to Windows, this time based on the Xbox 360 and PlayStation 3 versions with updated graphics. In contrast to the original port, this version features lighting effects, real-time instead of rendered cutscenes (except in the Separate Ways campaign), mouse support and Steamworks integration.

This version features all previously seen additional content, including the achievements from the latest HD Console versions. The game can be played with SD and HD quality textures, a filter option and an FPS lock option was also added allowing the user to select from 30 or 60 FPS options.