Anomaly Defenders is the closing installment of the Anomaly series. The original incarnation of the Tower Offense sub-genre had players controlling humans fighting alien invaders. Now, the tables have turned. The human counterattack is underway and the alien homeworld is under threat. Defend the planet from the human scum in the final battle of the series.

Anomaly Defenders is a fast-paced Tower Defense game where attacking human troops can damage and destroy your defenses. You have to react and counterattack enemies on the battlefield at all times. Each time you start a campaign, the unique tech-tree technologies can be tailored to your needs. Killing humans is easier due to 8 upgradable towers and special functions: repair your towers, make them go berserk, sacrifice them in explosions that are harmful to nasty humans, and use other tricks. This is the final battle against the humans. For the Hive, Commander!